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Appointment Hotline: (214) 390-7557

New / Potential Therapies in Dallas, TX

Nothing on this page is meant as a recommendation. These are just ideas that may prove to be useful after trials are done.

Experimental medications not available yet

  • NACE2i – restores ACE2 receptor function
  • BC007– works like an antibody

Useful Medications for Long Covid

  • Pyridostigmine (Mestinon)
  • Low dose naltrexone (LDN)
  • Maraviroc
  • Guanfacine or clonidine
  • Midodrine
  • Metformin
  • Low dose abilify (aripiprazole)

Useful Supplements

  • Nattokinase
  • N-acetyl cysteine (NAC)
  • Curcumin
  • Bromelain
  • Quercetin

Other medication ideas (no trials yet)

  • Rapamycin: mTOR inhibitor

Anti-CD20 monoclonal antibodies

  • Rituximab (Rituxan) – anti cancer medication that targets the CD20 of B cells.  Used for autoimmune conditions.
  • ocrelizumab
  • ofatumumab
  • ublituximab

 

Anti inflammatories

  • pegcetacoplan – C3 (complement) blocker
  • danicopan – anti-factor D antibody
  • iptacopan -anti-factor B antibody
  • hydroxychloroquine (HCQ)
  • chantix (Varenicline)
  • methotrexate –  causes cells to release adenosine which blocks chemicals that promote inflammation.
  • colchicine – prevents microtubule assembly and thereby disrupts inflammasome activation, microtubule-based inflammatory cell chemotaxis, generation of leukotrienes and cytokines, and phagocytosis. Many of these cellular processes can be found in other diseases involving chronic inflammation. 

 

TNF inhibitors – many are subcutaneous and may only need 1-2 injections.

  • Adalimumab (Humira)
  • Adalimumab-adbm (Cyltezo) a biosimilar to Humira
  • Adalimumab-adaz (Hyrimoz), a biosimilar to Humira
  • Adalimumab-atto (Amgevita), a biosimilar to Humira
  • Hadlima (Humira biosimilar in outside USA)
  • Certolizumab pegol (Cimzia)
  • Etanercept (Enbrel)
  • Etanercept-szzs (Ereizi), a biosimilar to Enbrel
  • Golimumab (Simponi, Simponi Aria)
  • Infliximab (Remicade)
  • Infliximab-abda (Renflexis) a biosimilar to Remicade
  • Infliximab-dyyb (Inflectra), a biosimilar to Remicade
  • Tocilizumab (Actemra)

 

JAK inhibitors drugs currently available in the United States:

  • Xeljanz (tofacitinib)
  • Olumiant (baricitinib)
  • Jakafi (ruxolitinib)
  • Rinvoq (upadacitinib)
  • Inrebic (fedratinib)
  • Cibinqo (abrocitinib)
  • Opzelura (ruxolitini)

 

Interleukin inhibitors

·       Most of these are monoclonal antibodies against the specific interleukin receptor and/or the receptor.

·       Interleukins serve as messengers of inflammation.

IL-1 inhibitors – mainly used for rheumatoid arthritis

  • anakinra (IL-1) – kineret
  • rilonacept (IL-1) – arcalyst
  • canakinumab (IL-1) – Ilaris

 

IL-4 & 13 – atopic dermatitis (eczema)

  • dupilumab – dupixant

 

IL-5 inhibitors – asthma, eosinophilic diseases, mast cells are also affected by IL-5, may be useful for MCAS.

  • benralizumab – fasenra
  • mepolizumab – nucala
  • reslizumab – cinqair

 

IL-6 inhibitors – useful in autoimmune inflammatory conditions such a rheumatoid arthritis.

  •        tocilizumab (IL-6) – actemra
  •       olokizumab (IL-6) – Artlegia – bind IL-6 directly
  •        clazakizumab (IL-6) – Ocaliva
  •        sirukumab (IL-6)  – was rejected due to deaths
  •        sarilumab (IL-6) – Kevzara

 

Other interleukin inhibitors

IL-17: Psoriasis, psoriatic arthritis, ankylosing spondylosis, rheumatoid arthritis.

IL-23:  treat plaque psoriasis, psoriatic arthritis, and Crohn’s disease.

  •        ustekinumab (IL-12/23) – Stelara
  •        brodalumab (IL-17) – Siliq
  •        secukinumab (IL-17) – cosentyx
  •        ixekizumab (IL-17) – Taltz
  •        guselkumab (IL-23) – tremfy

Other/Peptides

  • Honokiol – targeting mitochondrial dysfunction
  • rifaximin – gastric antibiotic meant for SIBO
  • larazotide – peptide, zonulin antagonist, improves tight junctions barrier in gut
  • human ezrin peptide

Try The GROYSMAN METHOD

See how your symptoms connect

Dr. Groysman’s educational tools for Long COVID and ME/CFS help you sort what you feel by the body systems associated with it, notice what sets it off, and prepare more focused questions for your next appointment. No account needed.

(For educational purposes only)

Explore the tools

See how your symptoms connect.

Dr. Groysman’s tools for Long COVID and ME/CFS. No account needed.

(For educational purposes only)

Explore the tools
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