New / Potential Therapies in Dallas, TX

Nothing on this page is meant as a recommendation. These are just ideas that may prove to be useful after trials are done.

Anti-CD20 monoclonal antibodies

Rituximab (Rituxan) – anti cancer medication that targets the CD20 of B cells. Used for autoimmune conditions.
ocrelizumab
ofatumumab
ublituximab

Anti inflammatories

pegcetacoplan – C3 (complement) blocker
danicopan – anti-factor D antibody
iptacopan -anti-factor B antibody
hydroxychloroquine (HCQ)
chantix (Varenicline)
methotrexate – causes cells to release adenosine which blocks chemicals that promote inflammation.
colchicine – prevents microtubule assembly and thereby disrupts inflammasome activation, microtubule-based inflammatory cell chemotaxis, generation of leukotrienes and cytokines, and phagocytosis. Many of these cellular processes can be found in other diseases involving chronic inflammation.

TNF inhibitors – many are subcutaneous and may only need 1-2 injections.

JAK inhibitors drugs currently available in the United States:

Interleukin inhibitors

· Most of these are monoclonal antibodies against the specific interleukin receptor and/or the receptor.

· Interleukins serve as messengers of inflammation.

IL-1 inhibitors – mainly used for rheumatoid arthritis

IL-4 & 13 – atopic dermatitis (eczema)

IL-5 inhibitors – asthma, eosinophilic diseases, mast cells are also affected by IL-5, may be useful for MCAS.

IL-6 inhibitors – useful in autoimmune inflammatory conditions such a rheumatoid arthritis.

Other interleukin inhibitors

IL-17: Psoriasis, psoriatic arthritis, ankylosing spondylosis, rheumatoid arthritis.

IL-23: treat plaque psoriasis, psoriatic arthritis, and Crohn’s disease.

Honokiol – targeting mitochondrial dysfunction
rifaximin – gastric antibiotic meant for SIBO
larazotide – peptide, zonulin antagonist, improves tight junctions barrier in gut
human ezrin peptide