Mitochondrial Dysfunction Protocol: Restoring Cellular Energy
How does Mitochondrial Dysfunction impact and Long COVID?
Mitochondria, often called the powerhouses of the cell, are organelles that produce Adenosine Triphosphate (ATP), the cell’s primary energy currency, through oxidative phosphorylation.
They also regulate cellular metabolism, apoptosis (cell death), and Reactive Oxygen Species (ROS) production.
Long COVID has been shown to directly impact mitochondria, damaging their ability to produce energy efficiently and contributing to widespread symptoms like fatigue, brain fog, shortness of breath, and muscle weakness.
This damage occurs through impaired oxidative phosphorylation, increased ROS production, and mitochondrial DNA damage, leading to cellular energy deficits and tissue damage.
You deserve to feel your best.
Symptoms Linked to Mitochondrial Dysfunction
General Symptoms
- Persistent fatigue that does not improve with rest.
- Exercise intolerance, causing rapid exhaustion and muscle weakness
Neurological Symptoms
- Muscle weakness and cramps, especially in energy-intensive muscles.
- Neuropathy: numbness, tingling, or pain in the extremities.
- Cognitive impairment, including difficulties with memory and concentration (brain fog).
- Ataxia: loss of coordination and balance.
Gastrointestinal Symptoms
- Bloating, nausea, and vomiting.
- Gastroparesis: delayed stomach emptying.
- Constipation or diarrhea due to impaired motility.
Cardiovascular Symptoms
- Cardiomyopathy: weakened heart muscle function.
- Arrhythmias and irregular heartbeats.
- Hypotension, especially orthostatic hypotension.
Respiratory Symptoms
- Shortness of breath, particularly during exertion.
- Respiratory muscle weakness, leading to ineffective breathing.
Endocrine Symptoms
- Thyroid dysfunction, including hypothyroidism or hyperthyroidism.
- Insulin resistance and diabetes mellitus.
Visual and Auditory Symptoms
- Vision problems, such as double or blurry vision.
- Hearing loss, often progressive.
Renal and Hematological Symptoms
- Kidney dysfunction, including conditions like Fanconi syndrome.
- Anemia, leading to fatigue and pallor.
Dermatological and Musculoskeletal Symptoms
- Skin rashes and hair loss.
- Osteopenia or osteoporosis, causing brittle bones and fractures.
- Mitochondrial myopathy: muscle weakness, exercise intolerance, and cramps.
How Does Dr. Groysman Address Mitochondrial Dysfunction?
Dr. Groysman has developed a 4 step system focusing on:
- Oxidative stress reduction
- Mitophagy/ autophagy
- Biogenesis of new mitochondria
- Mitochondrial function support
Dr. Groysman’s protocol targets the root causes of mitochondrial dysfunction using evidence-based therapies and interventions, including:
Nutritional Support:
- Supplements like Coenzyme Q10, L-carnitine, NAD+ precursors, and alpha-lipoic acid to enhance energy production and reduce oxidative stress.
- Bioactive compounds such as resveratrol, apigenin, and urolithin A to promote mitophagy and repair damaged mitochondria.
Physical Activity:
- Graded exercise therapy tailored to the patient’s tolerance to improve mitochondrial efficiency without triggering post-exertional malaise.
Lifestyle Modifications:
- Techniques like intermittent fasting to stimulate mitochondrial repair and apoptosis.
- Stress management strategies to reduce systemic inflammation.
Dietary Interventions:
- Anti-inflammatory and nutrient-dense diets tailored to support cellular health.
- Avoidance of processed foods and sugars that exacerbate oxidative stress and inflammation.
Why Addressing Mitochondrial Dysfunction Matters in Long COVID
Mitochondrial health is essential for the body to function properly. When mitochondria are damaged, cells cannot produce enough energy, which leads to widespread symptoms.
By targeting the root cause and enhancing mitochondrial function, patients can experience significant improvements in energy levels, cognitive clarity, and overall well-being.
What to Expect From Us
Comprehensive Evaluation: A thorough assessment of your symptoms, medical history, and risk factors related to mitochondrial dysfunction.
Diagnostic Testing: Advanced testing to measure mitochondrial biomarkers, oxidative stress levels, and energy production efficiency.
Personalized Plan: An integrative approach combining targeted supplements, dietary strategies, and lifestyle modifications to enhance mitochondrial function.
Ongoing Monitoring: Regular check-ins to ensure therapy effectiveness and optimize protocols based on progress.
Frequently Asked Questions
Mitochondrial dysfunction contributes to chronic fatigue, cognitive disturbances, and exercise intolerance in Long COVID. It leads to energy deficits and increased oxidative stress, explaining the persistence and diversity of symptoms.
The virus directly impairs mitochondrial bioenergetics and triggers immune responses that exacerbate damage. This disruption leads to systemic metabolic disturbances.
Elevated markers of oxidative stress, such as F2-isoprostanes and malondialdehyde, alongside reduced antioxidants like coenzyme Q10, can signal mitochondrial damage.
Yes, approaches like supplements, lifestyle changes, and dietary modifications have shown promise in enhancing mitochondrial function and alleviating symptoms, though ongoing research is crucial.
Persistent mitochondrial impairment can affect organ function and overall health. Addressing these issues is vital for recovery.
Similar patterns of mitochondrial dysfunction are seen in other post-infectious conditions, suggesting common pathways that may be targeted for treatment.
Patient Success Stories
My husband had the stellate ganglion block done by Dr Groysman on September 3rd and he immediately had his energy back, could sleep even better then before he got long covid, no more horse voice after talking in meetings and he can finally work and travel again like before LC. I can’t thank Dr Groysman enough for giving him his life back. – Jms 9/19/2024
Reclaim Your Energy Today
Don’t let fatigue and brain fog hold you back. Schedule a consultation with Dr. Groysman to learn how a personalized mitochondrial dysfunction protocol can help you regain control of your health and vitality.
Power up your cells. Power up your life.