Injection & Infusion Therapies for Long COVID Recovery
IV and injection therapies deliver nutrients, antioxidants, and medications directly into the bloodstream, bypassing the gut absorption issues common in Long COVID. Treatments include NAD+ for mitochondrial energy, glutathione for oxidative stress, B12 for neurological support, and 14 additional therapies targeting specific Long COVID mechanisms. All protocols are individualized based on comprehensive evaluation. Dr. Groysman offers these therapies within a mechanism-based diagnostic framework at his Plano, TX clinic.
You Tried The Supplements. You Adjusted Your Diet.
You are doing everything your providers have asked, and your body still is not recovering the way it should.
This is one of the patterns I see often in my Long COVID patients. The issue is not effort or compliance. In many cases, the issue is delivery. When gut dysfunction, chronic inflammation, or cellular damage limit what your body can absorb through digestion, oral supplements may never reach the cells needing them most. This is where IV and injectable therapies become relevant.
Intravenous administration delivers nutrients, medications, and therapeutic compounds directly into the bloodstream, bypassing the digestive system entirely. This means increased bioavailability compared to the absorption of typical oral supplements. For Long COVID patients dealing with gut dysbiosis, malabsorption, or significantly depleted nutrient stores, this difference can be clinically meaningful.
Each therapy below is administered under medical supervision, with protocols individualized based on comprehensive evaluation, laboratory findings, and the specific mechanisms driving your symptoms.
Which Mechanism Is Driving Your Symptoms?
Long COVID rarely has a single cause. In my clinical experience, most patients have two or more of these root mechanisms working simultaneously. Understanding which mechanisms are active helps determine which therapies are most appropriate for you.
Use your primary symptoms as a guide:
| Mechanism | Primary Symptom | Therapy |
|---|---|---|
| Mitochondrial Dysfunction | Fatigue, post-exertional crashes, brain fog | NAD+, L-Carnitine, B Complex, CoQ10 support, Amino Acids |
| Dysautonomia | Dizziness, racing heart, blood pressure instability, temperature dysregulation | IV Fluids/Saline, Trace Minerals, B12, Myers Cocktail |
| Gut Dysbiosis | Bloating, food intolerances, poor supplement absorption, altered stool patterns | B12, B Complex, Myers Cocktail, Amino Acids, Trace Minerals |
| MCAS / Histamine | Flushing, hives, reactions to foods/smells/heat, symptoms that fluctuate rapidly | Glutathione, Selenium |
| Endothelial Dysfunction / Microclots | Shortness of breath with normal oxygen levels, cold hands/feet, exercise intolerance, headaches with visual aura | Phosphatidylcholine, Glutathionessh shaun@78.47.245.109ti |
| Hormone Imbalance | Morning fatigue, weight changes, menstrual irregularities, poor stress tolerance, low libido | Iron, B12, Selenium, Trace Minerals |
| Viral Reactivation | Persistent symptoms despite other treatments, confirmed EBV reactivation on labs | Ganciclovir IV |
| Metabolic Dysfunction | Weight gain, insulin resistance, persistent inflammation, metabolic dysfunction | GLP-1 Agonist Injections |
| Multiple / Complex | Severe or refractory Long COVID, persistent organ damage | Stem Cells, Cell Factor Infusions |
Most patients benefit from therapies across multiple categories. During your consultation, Dr Groysman can evaluate which mechanisms are most active in your case and build a protocol addressessing them in the right sequence.
Energy and Mitochondrial Support
When mitochondria can’t meet energy demand, fatigue, brain fog, and post-exertional crashes often follow. In my Treatment Protocol, foundational antioxidant and mitochondrial support comes first: stabilize and protect mitochondria before attempting deeper repair. The infusion therapies in this category deliver key mitochondrial cofactors directly to cells, bypassing the gut absorption issues often limiting oral supplementation.
NAD+ (Nicotinamide Adenine Dinucleotide) IV Infusion
NAD+ is a critical coenzyme found in every cell of the body, essential for cellular energy production, DNA repair, and mitochondrial function. Research suggests that SARS-CoV-2 infection may disrupt NAD+ metabolism, contributing to the mitochondrial dysfunction, inflammation, and cellular energy deficits commonly seen in Long COVID. NAD+ is also essential for sirtuin activity, which plays a role in mitochondrial repair and energy metabolism.
L-Carnitine IV
L-carnitine is an amino acid derivative essential for transporting fatty acids into mitochondria, where they are converted into cellular energy (ATP). In Long COVID patients experiencing mitochondrial dysfunction and chronic fatigue, L-carnitine supplementation may help support the body’s ability to utilize fat for energy production. This is particularly relevant when cellular energy metabolism is impaired.
IV Amino Acid Blends (Including BCAAs)
Amino acids are the building blocks of proteins and play essential roles in tissue repair, neurotransmitter production, immune function, and energy metabolism. Branched-chain amino acids (BCAAs), leucine, isoleucine, and valine, are particularly important for muscle preservation and can serve as alternative energy substrates when cellular metabolism is compromised.
Antioxidant Support
Oxidative stress is a common thread across multiple Long COVID mechanisms. When the body’s antioxidant defenses are overwhelmed, mitochondria sustain further damage, endothelial cells become inflamed, and mast cells become more reactive. The therapies in this category support the body’s antioxidant defense systems, with glutathione serving as the foundation.
Glutathione (IV/Injection)
Glutathione is your body’s master antioxidant, critical for protecting cells, repairing tissue, and detoxifying harmful substances. Many Long COVID patients are believed to have depleted glutathione stores, which may worsen oxidative stress and slow healing. N-acetyl cysteine (NAC), a precursor to glutathione, is a key component of foundational mitochondrial support. IV glutathione delivers this antioxidant directly into the bloodstream, bypassing digestive limitations.
Selenium IV
Selenium is an essential trace mineral that functions as a critical component of selenoproteins, including glutathione peroxidase and thioredoxin reductase, which protect mitochondria from peroxide damage. Selenium also plays important roles in thyroid hormone metabolism and may help regulate inflammatory responses. Research suggests that selenium levels can be depleted during viral infections and chronic illness.
Nutritional Optimization
B vitamins are critical cofactors for mitochondrial enzymes. In my foundational protocol, B1 (thiamine) supports pyruvate dehydrogenase activity, B2 (riboflavin) supports the electron transport chain, B5 (pantothenate) is essential for coenzyme A in energy metabolism, and B12 (cobalamin) supports methylation and myelin protection. When gut dysfunction impairs absorption of these essential nutrients, IV delivery ensures they reach the cells that need them.
B12 (Methylcobalamin) Injection
Vitamin B12 is essential for neurological function, red blood cell formation, DNA synthesis, and energy metabolism. B12 deficiency can cause neurological symptoms including brain fog, memory problems, numbness, and fatigue, symptoms that overlap significantly with Long COVID. Many Long COVID patients have gut dysfunction potentially impairing B12 absorption, even when dietary intake appears adequate.
B Vitamin Complex (IV/Injection)
B vitamins (B1, B2, B3, B5, B6, B7, B9, B12) function as essential cofactors in cellular energy production, particularly in mitochondrial metabolism. These vitamins work synergistically to support the conversion of food into ATP (cellular energy), neurotransmitter synthesis, red blood cell production, and DNA repair. In Long COVID, where mitochondrial dysfunction and cellular energy deficits are common, B vitamin support may help address multiple metabolic bottlenecks simultaneously.
Myers Cocktail IV
The Myers Cocktail is a well-established IV nutrient formula containing vitamin C, B complex vitamins (B1, B2, B3, B5, B6, B12), magnesium, calcium, and often glutathione. This combination addresses nutritional deficiencies and supports overall cellular function through direct intravenous delivery, bypassing digestive limitations.
IV Trace Mineral Mixtures
Trace minerals including zinc, copper, manganese, chromium, molybdenum, and selenium are essential micronutrients required in small amounts for hundreds of enzymatic reactions throughout the body. These minerals support immune function, antioxidant defense, energy metabolism, hormone production, and tissue repair. Chronic illness and inflammation can deplete trace mineral stores, creating metabolic bottlenecks that impair recovery.
Iron Infusions
Iron is essential for oxygen transport via hemoglobin in red blood cells, energy production in mitochondria, and numerous enzymatic processes. Recent research has identified iron dysregulation as a potential key factor in Long COVID, characterized by low serum iron despite adequate or elevated iron stores (ferritin). This pattern suggests that iron becomes “trapped” in storage rather than circulating where it is needed for red blood cell production and tissue oxygenation.
Cellular Repair
When the endothelium (blood vessel lining) is damaged and coated in microclots, oxygen delivery to tissues drops. Phosphatidylcholine is a key component of both endothelial and mitochondrial membranes. Repairing these membranes is an important step in restoring blood flow and cellular energy production.
Phosphatidylcholine (PC) IV
Phosphatidylcholine is a fat-like molecule that makes up cell membranes, including those of the endothelium and mitochondria. In Long COVID patients with vascular damage or mitochondrial dysfunction, PC infusions may help support the repair of damaged vascular linings, membrane fluidity, and proper fat metabolism. This therapy is often followed by IV glutathione to help the body process toxins released during membrane repair.
Metabolic Support – GLP-1 Agonist Injections
GLP-1 (glucagon-like peptide-1) agonists such as semaglutide and tirzepatide are medications that mimic a natural hormone involved in blood sugar regulation, appetite control, and metabolic function. While originally developed for type 2 diabetes and obesity, emerging evidence suggests potential benefits for inflammatory conditions. Research indicates that COVID-19 patients taking GLP-1 agonists may have better outcomes, with some studies showing reduced risk of severe disease progression.
Viral Reactivation Support – Ganciclovir IV (for EBV Reactivation)
Ganciclovir is an antiviral medication that inhibits viral DNA replication, primarily used for cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections. Research has identified viral reactivation, particularly EBV, as a potential contributing factor in Long COVID. Studies show that COVID-19 can trigger EBV reactivation in a significant percentage of patients, and this reactivation may contribute to persistent symptoms.
Hydration and Volume Support – IV Fluids / Saline
IV fluid administration (normal saline or other balanced electrolyte solutions) provides direct hydration and volume expansion. For Long COVID patients with dysautonomia, dysfunction of the autonomic nervous system affecting heart rate, blood pressure, and blood vessel tone, IV fluids can provide significant symptom relief. Many Long COVID patients experience orthostatic intolerance (dizziness upon standing), inappropriate heart rate increases, and poor blood pressure regulation due to autonomic dysfunction.
Regenerative Medicine
Stem Cell Infusions
Mesenchymal stem cells (MSCs) are specialized cells with the ability to modulate immune responses, reduce inflammation, and support tissue repair through both direct cell replacement and paracrine signaling (secreting growth factors and other beneficial molecules). Recent clinical trials have evaluated stem cell therapy for COVID-19 and Long COVID, with emerging evidence suggesting potential benefits for lung repair, immune regulation, and symptom management.
Cell Factor Infusions
Cell factor infusions involve the delivery of bioactive molecules secreted by cells, including growth factors, cytokines, and exosomes, tiny vesicles that carry proteins, genetic material, and other signaling molecules between cells. These treatments draw on the regenerative signaling capabilities of stem cells without necessarily transferring the cells themselves. Exosomes and growth factors can support tissue repair, modulate immune function, and facilitate cellular communication.
What Our Patients Say
“I felt alive instead of barely living.” — J.D., Long COVID patient, after treatment at our clinic. J.D. had experienced over 4 years of fatigue and brain fog before seeking care.
“This is the first time in 3 years I started feeling like a human.” — I.T., who came to our clinic after 3 years of severe symptoms including excruciating pain, brain fog, and small fiber neuropathy. After treatment, neuropathy in feet, legs, and hands resolved, with approximately 80% overall improvement.
“I can breathe and I feel alive!” — Long COVID patient from Iowa, who had spent 4+ years dealing with dysautonomia, mitochondrial dysfunction, chronic fatigue, brain fog, and memory loss before seeking comprehensive treatment.
These testimonials reflect individual patient experiences with comprehensive Long COVID treatment at our clinic. Individual results vary. Treatment protocols are personalized based on each patient’s evaluation and mechanism profile.
Who Can Benefit from Injection and Infusion Therapy
You may be a candidate for injection and infusion therapies if you have:
- Persistent fatigue despite adequate rest and sleep
- Mitochondrial dysfunction or cellular energy deficits
- Brain fog, cognitive difficulties, or neurological symptoms
- Gut dysfunction limiting nutrient absorption from oral supplements
- Documented nutritional deficiencies (B12, iron, minerals)
- Dysautonomia or orthostatic intolerance symptoms
- Chronic oxidative stress or detoxification challenges
- Confirmed viral reactivation (EBV, CMV)
- Metabolic dysfunction or weight management challenges
- Long COVID symptoms not responding to standard approaches
Comprehensive evaluation helps determine which therapies are most appropriate for your individual symptom profile, medical history, and treatment goals.
What to Expect from Treatment
Initial Consultation: Dr Groysman will review your medical history, symptoms, current medications, and lab work to determine which injection or infusion therapies might be a fit. The evaluation process identifies which of the root mechanisms are most active in your case, allowing treatment selection to target the right pathways. Some treatments require specific testing before initiation (such as iron panel before iron infusions).
Treatment Sessions: Most IV infusions take 30 minutes to 2 hours, depending on the specific therapy. You will be monitored during treatment, and infusion rates can be adjusted for comfort. Many patients read, work on laptops, or rest during sessions.
Response Timeline: Some patients notice improvements after a single session, while others require several weeks of consistent treatment before experiencing significant benefits. Individual results vary based on the underlying mechanisms being addressed and overall health status.
Monitoring: Regular follow-up appointments and lab work help track your response to treatment and allow for protocol adjustments as needed. Some therapies require ongoing monitoring for safety.
Frequently Asked Questions
Schedule Your Consultation
If your Long COVID symptoms have not responded to standard approaches, or if you suspect that gut dysfunction is limiting what your body can absorb from oral supplements, a comprehensive evaluation can clarify your specific path forward.
Our evaluation process identifies which root mechanisms are driving your symptoms, determines which therapies match your mechanism profile, and creates a personalized protocol targeting the right pathways in the right sequence.
Most IV infusions take 30 minutes to 2 hours depending on the specific therapy and your individual protocol. NAD+ infusions typically take 1-2 hours to allow for comfortable administration and optimal absorption, while vitamin and mineral infusions like Myers Cocktail or glutathione often complete in 30-60 minutes. B12 and other intramuscular injections take only 5-10 minutes. During your consultation, we will discuss the expected duration for your personalized treatment plan.
Treatment frequency varies based on the specific therapy and your individual needs. Many patients start with weekly infusions during the initial phase to address deficiencies and support recovery, transitioning to biweekly or monthly maintenance sessions as symptoms improve. Some therapies like B12 injections may be administered weekly to monthly depending on deficiency severity, while others like stem cell infusions follow different protocols. Your provider will create a personalized schedule based on your symptom profile, lab results, and response to treatment.
Our clinic does not accept insurance for injection and infusion therapies. Investment varies by treatment type, frequency, and protocol duration. During your consultation, your provider will discuss specific costs and help you understand the full scope of your personalized treatment plan. We can provide superbills and documentation for you to submit to your insurer for potential reimbursement. Contact our clinic at (214) 390-7557 for more information about treatment costs.
Yes, many therapies work synergistically and can be safely combined. For example, phosphatidylcholine infusions are often followed immediately by glutathione to support detoxification processes. Myers Cocktail already combines multiple nutrients (B vitamins, vitamin C, magnesium, calcium) in a single infusion. Your provider will recommend appropriate combinations based on your specific needs, ensuring safety and maximizing therapeutic benefit. Some combinations enhance effectiveness while reducing the total number of clinic visits required.
Response timelines vary significantly by individual, therapy type, and underlying condition severity. Some patients notice improvements after a single session, particularly with hydration therapy for dysautonomia or B12 injections for deficiency. However, therapies addressing deeper metabolic issues like mitochondrial dysfunction, nutritional deficiencies, or cellular repair often require several weeks of consistent treatment before significant benefits become apparent. Most protocols show meaningful improvements within 4-8 weeks. Your provider will discuss realistic expectations for your specific treatment plan.
Most IV therapies are well-tolerated when administered under proper medical supervision. Common temporary effects include mild flushing, warmth at the injection site, or a transient mineral taste during infusion. Some patients experience temporary fatigue or mild nausea as the body processes nutrients and begins detoxification, this typically resolves within a few hours. Specific therapies have unique considerations: high-dose vitamin C requires G6PD screening to prevent serious reactions, ganciclovir requires blood monitoring for bone marrow effects, and phosphatidylcholine may cause temporary detox symptoms. Each treatment section above details specific safety considerations, and your provider will review all potential effects before treatment.
Baseline laboratory testing is beneficial for most IV therapies to identify specific deficiencies, customize protocols, and establish treatment targets. Common pre-treatment labs may include vitamin levels (B12, D, folate), mineral panels (zinc, selenium, magnesium), thyroid function, complete blood count, comprehensive metabolic panel, and other markers depending on your symptoms. For certain therapies like iron infusions or high-dose vitamin C, specific testing is mandatory for safety (ferritin/iron panel, G6PD screening). Lab results help your provider select the most appropriate therapies and dosing for your individual needs.
Selecting appropriate therapies requires comprehensive evaluation of your symptoms, medical history, current medications, lab results, and which Long COVID mechanisms are most active in your case. During your initial consultation, your provider will review your symptom profile (fatigue, brain fog, dysautonomia, etc.), identify which underlying mechanisms are likely involved (mitochondrial dysfunction, oxidative stress, nutritional deficiencies, viral reactivation), and recommend therapies targeting your specific issues. Many patients benefit from a combination approach, for example, mitochondrial support (NAD+, L-carnitine) plus antioxidant protection (glutathione) plus nutritional optimization (B vitamins, minerals). Treatment plans are individualized and adjusted based on your response.
IV and injectable therapies offer several advantages over oral supplementation, particularly important for Long COVID patients. First, bioavailability: IV administration provides absorption directly into the bloodstream, while oral supplements typically achieve only 20-50% absorption depending on gut function. Second, therapeutic IV dosing allows for much higher doses than could be tolerated orally (for example, 25 grams of vitamin C IV compared to 1-2 grams oral maximum before GI distress). Third, bypassing gut dysfunction, many Long COVID patients have impaired digestion, leaky gut, or malabsorption issues that limit oral supplement effectiveness. IV therapy delivers nutrients directly to cells regardless of gut status. Finally, immediate availability: IV nutrients are immediately available for cellular use, while oral supplements require digestion, absorption, and processing.
Call (214) 390-7557 to schedule your injection and infusion therapy consultation.
Individual results vary. These therapies are used to support various aspects of health and recovery but are not intended to diagnose, treat, cure, or prevent any disease. All treatments are administered under medical supervision with individualized protocols based on comprehensive evaluation. Treatment decisions are made collaboratively between you and your provider based on laboratory findings, clinical assessment, and your individual treatment goals.